Recent Study Shows Stromal Cells From Bone Marrow Boosts Breast Cancer Growth

A recent study conducted by Professor Neta Erez of the Sackler School of Medicine at Tel Aviv University has shown that stromal cells produced in the bone marrow can fuel the growth of cancerous breast tumors.

In breast cancer, tumors are often surrounded by a variety of cells that fuel the growth of cancer by aiding in the creation of new blood vessels, causing inflammation, and increasing the multiplication of cancerous cells. These non-cancerous cells that aid the growing tumor often come from tissue in the surrounding area. For example, in breast cancer, these fibroblasts frequently originate in the breast tissue.

Professor Erez and her fellow researchers found that fibroblasts that come from bone marrow actually play a large role in the growth of the tumor. They studied mice with breast cancer and discovered that these cells that are recruited from the bone marrow are especially effective in the formation of blood vessels.

This creation of new blood vessels is beneficial to cancer because it allows for oxygen and nutrients to reach the tumor, but it is detrimental to the patient because this fuels the growth of the cancerous cells.

Erez is optimistic that this new research will lead to new methods of treatment that take advantage of the discoveries. She stated “Understanding the function of these cancer-associated fibroblasts could form the basis of developing novel therapeutic manipulations that co-target bone marrow-derived fibroblasts as well as the cancer cells themselves.”

If you found this story interesting you should consider reading about Seattle-based Atossa Genetics (Nasdaq: ATOS) which is is a clinical-stage drug company developing novel, proprietary therapeutics and delivery methods for breast cancer and other breast conditions. To learn more please see Atossa the dedicated coverage page at Vista Partners.

 

 

 

 

 

 

 

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“Ups and Downs” – Vista Partners Daily Market Recap 11/27/2018

The market saw plenty of ups and downs during trading on Tuesday before all three of the major indexes ended the day just barely up from open. The Nasdaq edged up just 0.01% (0.85 points) and the S&P 500 gained 0.33% (8.75 points). The Dow rose 0.44% (108.49 points).

Individual components of the Dow were mixed today with some winners and some big losers. On the losing side, United Technologies Corporation (UTX) saw shares slip 4.14% by the market’s close after announcing a breakup plan. Under the plan, UTX will create an aerospace company consisting of Collins Aerospace Systems & Pratt & Whitney and Carrier. On the other hand, Verizon (VZ) did well with gains of 2.50%, and Walgreens (WBA) rose 2.23% to end the session.

Atossa Genetics (ATOS) had a down day with shares dropping 3.33%.

The bumpy market today was due in part to investors reactions to a pair of news stories. The first was released by the Wall Street Journal last night. In it, President Donald Trump stated that it is very possible that he will increase the current 10% tariff on Chinese imports to 25% and that if a fair deal is not reached with Chinese President Xi Jinping, he may impose tariffs on the remaining Chinese goods that have been so far unaffected.

The other story came from remarks made by the Fed’s Vice Chairman Richard Clarida. He seemed optimistic about the economy in his remarks and noted that the Fed should be gradual in their interest rate hikes. He also noted that interest rates are “much closer” to neutral compared to 2015. “How close is a matter of judgment, and there is a range of views on the FOMC.” In remarks from two weeks ago, Clarida stated that he believed a neutral rate would be between 2.5% to 3.5% in comparison to the current level between 2.0% and 2.25%.

Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

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Stocks close higher

Stocks ticked up Tuesday as traders digested recent trade comments from President Donald Trump and remarks from a Federal Reserve official pointing toward future gradual interest rate hikes…

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“A Good Day” – Vista Partners Daily Market Recap 11/26/2018

After last week’s rocky performance, US stocks had a good day on Monday with all three of the major indices seeing gains. The Nasdaq climbed 2.06% (142.87 points) and the S&P 500 gained 1.55% (40.89 points). As trade ended, the Dow had risen 1.46% (354.29 points).

Nearly every component of the Dow saw gains today with American Express (AXP) leading the charge as it rose 3.73%. Microsoft (MSFT), trying to rebound after a notably hard week for tech stocks, wasn’t too far behind with an increase of 3.30%. The Travelers Companies (TRV) also did quite well as it saw gains of 2.93%.

Atossa Genetics (ATOS) also shared in the upswing today as it saw shares increase 5.26%.

The VelocityShares Daily 2x VIX ST ETN (TVIX), broad-based leveraged bet against the market,  dropped 11.25% today to close at $44.82. We believe that the TVIX will see a move back to positive territory by the end of the week that could begin as soon as Wednesday as we speculate that the markets will again be selling off by week’s end.

After a very successful Black Friday, in which online sales increased to $6.22 billion (up 23.6% from the year before), today’s Cyber Monday is expected to continue the trend. Nearly $2 billion of the Black Friday total came from shopping done on smartphones. These numbers along with the fact that in-store shopping decreased 1.7%, has some feeling good about the future of tech stocks despite a rough last week.

Aaron Kessler, a Raymond James Analyst, noted: “E-commerce sales as reported by numerous sources indicate solid holiday sales for the Thanksgiving weekend and holiday season to date and we remain comfortable with our expectation for mid-teens e-commerce holiday season growth.” He also stated that he is keeping “a positive bias on Amazon and Google shares.”

Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

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Stocks rebound, crude oil prices rise

Stocks climbed after Friday’s equity rout capped off an abbreviated week of wobbly trading. ..

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“Vista’s View – A Weekly FREE Market Update 11-24-18″…Now Available!

Vista Partners has published “Vista’s View – A Weekly Market Update Newsletter 11-24-18!”  Each weekly newsletter is written by Vista Partners’ Managing Director, John Heerdink.   Vista’s View includes an exclusive view on the stock market for the week, a “Stocks To Watch” section, featured stories that span from the Dow 30, select emerging growth companies, investing basics & exciting videos from Vista’s Coverage Universe and beyond.

Vista Covers all Dow 30 components, International Companies, Select Emerging Growth Companies & more on the website daily.

 Download the latest Exclusive FREE Newsletter at the Vista Partners’ Newsletters Page Now.  It’s FREE!!!

Stay Informed! Stay Competitive!  Receive our FREE emial updates by signing up today in just  few seconds!

 

 

 

 

 

Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

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“Black “Price Drop” Friday” – Vista Partners Daily Market Recap 11/23/2018

Prices weren’t the only thing dropping this Black Friday, US stocks also saw cuts during this holiday-shortened trading session that closed at 1pm eastern. The S&P 500 sank 0.66% (17.37 points) and the Dow dropped 0.73% (178.74 points). The Nasdaq also dipped into the red with losses of 0.48% (33.27 points) shedding some gains from earlier in the day.

In general, most components of the Dow saw shares decline today, but United Technologies Corporation (UTX) was able to buck that trend with gains of 2.65%. On the other side of the spectrum, Chevron (CVX) had the worst day with a loss of 3.38%. Exxon (XOM) was next to worst as it tumbled 2.66% by the end of trade day.

Seattle based Biotech firm Atossa Genetics (ATOS) also saw red as it dropped 5.00% today.

Despite the poor showing for stocks, Black Friday sales seem to be doing just fine. So far, it appears that online sales have spiked this year; as of 10 a.m., they were up 27.8% when compared to last year. Thanksgiving Day sales also impressed, demolishing previous records as they soared past $3.7 billion.

According to Taylor Schreiner from Adobe Digital Insights, “Mobile stole the show Thanksgiving day with smartphones representing more than 50% of traffic to retail sites, as well as a record amount of revenue.”

Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

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Stocks fall, oil dives to one-year low

Stocks fell and oil nosedived during Friday’s shortened trading session…

finance.yahoo.com

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“Clawing Back” – Vista Partners Daily Market Recap 11/21/2018

US stocks attempted to claw their way back up on Wednesday after suffering stark losses in this week’s previous sessions. The Nasdaq managed to gain 0.92% (63.43 points) while the S&P 500 notched an increase of 0.3% (8.04 points). Despite rallying 200 points at its high during intraday trading, the Dow ended the day with nearly no change (it was down less than 1 point).

Individually, components of the Dow were mixed today. Johnson & Johnson (JNJ) saw the greatest losses by a significant margin with a decline of 3.05%. Apple (AAPL) was down 0.11%, but declines were not nearly as steep as the previous two days. NIKE (NKE) saw the largest gains of any company in the index today with an increase of 1.76%.

Atossa Genetics (ATOS) wasn’t quite as lucky, its shares slipped 5.51% by market close.

With the recent downturn in the market, several people have the new expectation that the Fed will scratch its plan to hike rates again in December. Jan Hatzius of Goldman Sachs doesn’t see this as likely. She noted that unless other financial conditions crumble, the probability of the Fed changing course is slim.

Hatzius wrote, “We expect the Fed to hike at the December meeting despite the recent stock market decline, with a subjective probability of 90%. Subsequent moves will depend on the data, but our baseline forecast remains four more hikes in 2019 with risks that are broadly balanced.”

Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

Stay Informed! Stay Competitive!

S&P 500, Nasdaq close higher

Both the S&P 500 and Dow are still negative for the year-to-date…

finance.yahoo.com

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“A Spate of Factors” Vista Partners November 2018 Macro Economic and Investment Newsletter 11-21-18

Vista Partners (“Vista”) has published November’s FREE Macroeconomic & Investment Monthly Newsletter, “A Spate of Factors.”

Vista’s monthly newsletter contains investment considerations for Banks, Biotech, Cloud Services, Energy, Fintech, Healthcare, Manufacturing, Mining, Natural Resources, Oil & Gas, Real Estate, Silver, and Technology.

Vista Partners centers its Coverage on the Dow 30 Components, Select Emerging Growth Companies & Vista’s Featured Companies, with exclusive, broad-based commentary from Managing Director, John F. Heerdink, Jr.

In November’s edition of the Macroeconomic & Investment Newsletter, Mr. Heerdink states,

“This cooling is due to a spate of factors. Rising interest rates and”…….” Read full newsletter.

Companies Featured in November’s Newsletter:Atossa Genetics, Inc. (NASDAQ: ATOS)  | Cisco (CSCOFirst Majestic Silver Corp. (NYSE: AG) | Fusion, Inc. (NASDAQ: FSNN) | Roche (RHBBY) | Tesla (TSLA) & Travelers (TRV)

Vista Partners publishes 100% of its content free. Vista Partners offers a wealth of mixed-media resources on the Dow 30 & Select Emerging Growth Companies. To receive FREE email updates from Vista, please sign up at VistaPGlobal.com/signup.

About Vista Partners LLC:

Founded in 2005, Vista Partners LLC (“Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, and Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

We encourage readers to view a complete list of disclaimers and disclosures on the Vista Partners website at VistaPGlobal.com/disclaimer.

Please follow Vista Partners on Twitter @VistaPResearch to receive updates, thoughts, and ideas on Dow 30 Components, Select Emerging Growth Companies, Vista’s Featured Companies, International Companies, Pre-IPO Companies & Strategic Companies.

Contact:

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“Tanking” – Vista Partners Daily Market Recap 11/20/2018

US stocks tanked on Tuesday, as Monday’s sell-off continued. The S&P 500 sank 1.82% (48.84 points) while the Nasdaq fared about the same with a loss of 1.7% (119.6 points). The Dow had the worst day of the three, as it plummeted 2.21% (551.8 points).

Individual components of the Dow were down across the board, with every single stock ending the day in the red. The biggest losers were Apple (AAPL) with a loss of 4.78%, Goldman Sachs (GS) which sank 3.47%, and Walt Disney (DIS) with shares declining 3.08%.

Atossa Genetics (ATOS) shined today against a gloomy backdrop as it gained a whopping 9.48% for the day.

Our TVIX and TZA ETF leveraged bets against the broad markets and the Russell 2000 were once again up respectively 11.64% and 5.79%.

The markets losses today mean that both the Dow and the S&P 500 are in the negative for the year. The tech sector has been one of the major culprits in the declines, as each of the FANG components are down nearly 20% from their year highs.

According to Chris Zaccarelli, the chief investment officer of Independent Advisor Alliance, their are several factors working against the tech sector. “Tech continues to be caught in the crosshairs of the triple threat of rising interest rates, global growth fears, and trade tensions with China.”

Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

Stay Informed! Stay Competitive!

Dow, S&P 500 now down for 2018

Stock futures pointed to a sharply lower open, showing no respite after Monday’s equity rout…

finance.yahoo.com

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Roche’s Tecentriq Speeds Forward after Priority Designation from FDA

Roche’s Tecentriq continues to press forward in its attempt to become the first immuno-oncology drug approved for triple negative breast cancer treatment. The FDA helped to speed the process along on Tuesday by granting it a priority review designation.

The priority decision came after studies have shown positive results for a treatment program that combines Tecentriq with a chemo medicine called Abraxane. The results have shown that the regimen reduced the risk of the disease worsening or or death by 38%. On average, it was able to keep the aggressive cancer from progressing for 7.5 months while patients in the control group’s average was 5 months.

A decision on the drug should come by early March, 2019. If Tecentriq is OK’d it will become the first in its class to be approved for triple negative breast cancer treatment. This would put it alongside other Roche products like Herceptin as a trailblazer.

Sandra Horning, M.D., Roche’s chief medical officer, stated, “Tecentriq in combination with nab-paclitaxel has the potential to meaningfully advance treatment for people with PD-L1-positive, metastatic triple-negative breast cancer. People need more options for this type of breast cancer, which is particularly difficult to treat.”

If you found this story interesting you should consider reading about Seattle-based Atossa Genetics (Nasdaq: ATOS) which is is a clinical-stage drug company developing novel, proprietary therapeutics and delivery methods for breast cancer and other breast conditions. To learn more please see the dedicated coverage page at Vista Partners.

www.fiercepharma.com

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“Down, Down, Down” – Vista Partners Daily Market Recap 11/19/2018

US stocks were down on Monday with all three major indices seeing significant losses by the end of the session. The Nasdaq took the hardest hit, dropping 3.03% (219.4 points). The S&P 500 sank 1.67% (45.54 points), and the Dow saw a 1.56% (395.78 point) dive.

A turkey of a day for most but individually, some components of the Dow did much better than the index as a whole. Pfizer (PFE), for one, saw nice gains of 1.54% and Travelers’ (TRV) shares increased 1.36%. But several more companies were likely not as pleased with the results at the end of the day. Boeing (BA) led the declines with losses of 4.47%.

Outside the Dow, Atossa Genetics (ATOS) didn’t fare much better as it soldoff 4.92% by the time the market closed.

The sinking market was led again by tech stocks. Apple (APPL) shares sank 3.96% today after a report that they had decreased iPhone production. Facebook (FB), another of the tech giants, had an even worse day as its stock crashed 7.98% and even touched its 52-week low during trading today. It continues to combat fallout after a report about the way it managed the Cambridge Analytica ordeal.

Our TVIX ( a leveraged ETF bet against the market that we entered again at the end of trsding Friday jumped 11.23% today to close at $46.74.

Michael Wilson, with Morgan Stanley, noted on Monday that over 40% of S&P 500 stocks are down at least 20% for the year. Because of this he warned that “we are in the midst of a bear market.”

Vista Partners LLC (”Vista”) is a California Registered Investment Advisor based in San Francisco. Vista delivers timely and relevant insights via the website: www.vistapglobal.com with daily stories, weekly market updates, monthly macroeconomic newsletters, podcasts, & Vista’s proprietary equity and market research to help you stay informed and stay competitive. Vista’s mission is to invest partner capital while arming investors with a comprehensive global financial perspective across all market sectors. Vista also seeks to provide select issuers with actionable advice regarding fundamental development, corporate governance, and capital market directives.

Stay Informed! Stay Competitive!

Tech rout drags markets sharply lower

The Dow shed more than 500 points at its intraday low…

finance.yahoo.com

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